Home » Research » Liv.52(tablet,syrup)

Research papers: - Clinical Papers: 16, Experimental Papers: 48

Clinical Papers

    Chronic Liver Disease

  1. Hepatoprotective Effects of Liv.52 in Chronic Liver Disease Preclinical, Clinical, and Safety Evidence: A Review
    Chetan Kantharia (Department of Surgical Gastroenterology, Seth G S Medical College and K E M Hospital, Mumbai), Munesh Kumar (Department of Medicine, RUHS-CMS and Attached Hospital, Jaipur), Mukesh Kumar Jain (MG Medical College & Hospital, Jaipur), Lokendra Sharma (Department of Pharmacology, SMS Medical College, Jaipur), Lokesh Jain (Department of Hepatology, Mahatma Gandhi Medical College, Jaipur) and Anish Desai (Department of Pharmaceutical Medicine, Maharashtra University of Health Sciences, Nashik, India), Gastroenterol. Insights 2023, 14, 293308
    DOI: 10.3390/gastroent14030021

  2. Role of Liv.52 in Non-Infectious Chronic Liver Disease.
    Khalid Abdulla Al-Khazraji, Professor of Gastroenterology, College of Medicine, Baghdad University, Iraq, Ali Khalid, Baghdad Teaching Hospital, Iraq, Mohammed Kamal Hashim, Department of Surgery, Baghdad Teaching Hospital, Iraq, Mahmood Kamal Hashim, Department of Dermatology, Baghdad Teaching Hospital, Iraq, Safia Khalid Abdulla, College of Medicine, Al-Iraqia University, Iraq, Mohammed Khalid Abdulla, Medical student 4th grade, Baghdad Medical College, Iraq, Issam Hadi Khudhair, Medical student 6th grade, Pleven Medical University & Wissam Khudhair Abbas, College of Medicine, Al-Mustansiriya University, Iraq. Global Journal of Health Science Vol. 14, No. 7; 2022.
    DOI: 10.5539/gjhs.v14n7p76

  3. The efficacy of Liv.52 on liver cirrhotic patients: A randomized, double-blind, placebo-controlled first approach
    H. Fallah Huseini, Department of Pharmacology, Institute of Medicinal Plants, Tehran, Iran., S.M. Alavian, Baqiatallah University of Medical Sciences, Tehran Hepatitis Center, Tehran, Iran., R. Heshmat, Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran. M.R. Heydari, Endocrinology & Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran, K. Abolmaali Baqiatallah University of Medical Sciences, Tehran, Iran. Phytomedicine 12;(2005): 619-624.
    DOI: 10.1016/j.phymed.2004.10.003

    Non Alcoholic Fatty Liver Disease (NAFLD)

    Alcoholic Liver Disease (ALD)

  1. Clinical and Safety Evaluation of Liv.52 in Alcoholic Liver Disease: A Review
    Subramanian Ganesh, GE Clinic & Endoscopy Centre & MIOT Hospital, Chennai, India Neeraj Joshi, Nepal Mediciti Hospital and Nepal Cancer Hospital & Research Centre, Lalitpur, Nepal, Mukesh Kumar Jain, MG Medical College & Hospital, Jaipur, India, Lokendra Sharma, Department of Pharmacology, SMS Medical College, Jaipur, India, Anish Desai, Intellimed Healthcare Solutions, Mumbai, India, Mohamed Rafiq, Uddagiri Venkanna Babu and Rajesh Kumawat, Research and Development, Himalaya Wellness Company, Bengaluru, India. Gastroenterology Insights 2022, 13, 377386.
    DOI: 10.3390/gastroent13040037

  2. Evaluation of Efficacy and Safety of Liv.52 Tablet in Acute Alcoholic Hepatitis: An Open Clinical Study
    SV Dange, Abhijit Nikam, Mangesh Kamale. Consultant, Dhanashree Hospital, Sangavi, Pune. Indian Journal of Clinical Practice, Vol. 22, No. 7, December 2011: 325-329.

  3. Effect of the hepatoprotective drug Liv.52 on liver damage
    M. Kalab, T. Krechler, Internal Clinic of the Medical Faculty of the Charles University in Prague and The Military Faculty Hospital in Prague, The Journal of Czech Physicians (1997): (136), 24, 758-760.

  4. Effect Of Liv.52, A Herbal Preparation, On Absorption And Metabolism Of Ethanol In Humans
    Chauhan BL And Kulkarni RD, M.D., R and D Centre, The Himalaya Drug Co., Bombay. European Journal of Clinical Pharmacology (1991): 40, 189-191.
    doi: 10.1007/BF00280076

  5. Blood, urine ethanol and acetaldehyde levels from six different alcoholic beverages and effect of Liv.52
    Kulkarni, R.D. and Chauhan, B.L., The Himalaya Drug Co., R & D Centre, Bombay, India. European Journal of Pharmacology (1990): (183), 5, 1865.
    DOI:10.1016/0014-2999(90)92199-S

    Drug Induced Liver Injury (DILI)

  1. Liv.52 in the Prevention of Hepatotoxicity in Patients Receiving Antitubercular Drugs: A Meta-analysis
    SV Dange Professor, Dept. of Pharmacology DY Patil Medical College, Hospital and Research Centre, Pune, India. Indian Journal of Clinical Practice, Vol. 21, No. 2, July 2010: 81-86.

    Viral Hepatitis

  1. Effect of phytotherapy on prevention and elimination of hepatotoxic reactions in patients with pulmonary tuberculosis and carriers of hepatitis B virus markers
    Galitsky, L.A., Barnaulov, O.D., Zaretskii, B.V., Malkov, M.I., Konenkov, S.I., Gol'm, N.P., Tomakov, V.S., Ogarkov, P.I. and Batskov, S.S. Military Academy of Medicine, Human Brain Institute of the Russian Academy of Sciences, Saint-Petersburg, Russia. Problems of Tuberculosis, (1997): 4, 35.

  2. A Clinical Study of Infective Hepatitis Treated with Liv.52
    Ila V. Desai, Dudhia, M.V. and Gandhi, V.K. Sheth K.M. School of Post-graduate Medicine and Research and Sheth V.S. General Hospital and Smt. N.H.L. Municipal Medical College, Ahmedabad. Indian Pediatrics (1977): 3, 197. (https://www.indianpediatrics.net/1977/mar1977.htm)

  3. Efficacy of an indigenous compound preparation Liv.52 in acute viral hepatitis A double-blind study
    Sama, S.K., Krishnamurthy, L., Ramachandran, K. and Krishnan Lal, All India Institute of Medical Sciences, New Delhi, India. Indian Journal of Medical Research (1976): 5, 738.

  4. Viral hepatitis in children
    Sudhakar Rao, V., M.D., (Ped.), D.C.H. (Bom.), Reddi, Y.R., M.D., M.A.M.S., D.A.B.P. (U.S.A.), M.A.M.S., F.A.A.P., Rohini, K., M.D., D.C.H., and Institute of Child Health, Niloufer Hospital, Hyderabad, A.P. Indian Pediatrics (1975): (XII), 8, 659. (https://www.indianpediatrics.net/1975/aug1975.htm)

  5. Liv.52 studies in acute hepatitis
    Ramalingam V., Research Assistant, Sundarvalli, N., Assistant Professor of Paediatrics, and Balagopal Raju, V., Director, Supdt., and Professor of Paediatrics, Institute of Child Health & Hospital for Children, Egmore, Madras. Indian Pediatrics (1971): 12, 839. (https://www.indianpediatrics.net/1971/dec1971.htm)

    Others

  1. New Drug Development using Korean Herbal Formulae: A model role study
    Jung-Hyo Cho, Jing-Hua Wang, Chang-Gue Son, Liver-Immune Department of Daejeon Oriental Hospital of Daejeon University, South Korea. The Journal of Korean Oriental Medicine. 2009. Vol.30. No.6. 96-102.

  2. Observation on the Anabolic Effects of Liv.52 in Burns
    Sinha R.N., Singh Y. and Madan P. Department of Plastic Surgery, Patna Medical College Hospitals, Patna. Indian Journal of Plastic Surgery (1972): (5), 1, 26.

Experimental Papers

    Chemical / Drug induced Hepatotoxicity

  1. Prophylactic action of Liv.52 against Lanthanum chloride induced liver injury in male mice
    Sharma T, Sharma DK. Indian Journal of Science Research 2014; 5 (1): 67-70.

  2. Effect of Spirulina and Liv.52 on Cadmium induced Toxicity in Albino Rats
    Jeyaprakash K and Chinnaswamy P. Indian Journal of Experimental Biology 2005; 43:773-781.

  3. Hepatoprotective Effect of Liv.52 on Antitubercular Drug-induced Hepatotoxicity in Rats.
    Vijaya Padma V, Suja V, Shyamala Devi CS and Prema.Fitoterapia 1998; LXIX (6):520-522.

  4. Hepatoprotective effect of Liv.52 and Kumaryasava on carbon tetrachloride-induced hepatic damage in rats
    Meena Kataria and Singh, L.N. Indian Journal of Experimental Biology 1997; 35: 655-657.

  5. Influence of Liv.52 on carbon tetrachloride-induced hepatotoxicity: A biochemical study
    Goel A, Dhawan DK, Gautam CS. Indian Journal of Pharmacology 1991; 23: 182-184.

  6. In vitro effect of an Ayurvedic liver remedy on hepatic enzymes in carbon tetrachloride treated rats.
    Piyush Bardhan, Sharma SK and Garg NK. Indian Journal of Medical Research 1985; 82:359.

  7. An Experimental Evaluation of Protective Effects of Some Indigenous Drugs on Carbon Tetrachloride-induced Hepatotoxicity in Mice and Rats
    Singh NNR, Gupta ML and Kohli RP. Quarterly Journal of Crude Drug Research 1978; 16(1): 8-16.

  8. Changes in serum transaminases due to hepatotoxicity and the role of an indigenous hepatotonic Liv.52.
    Subbarao VV and Gupta ML. Yugoslavia Physiologica Pharmacologica Acta (1976): 12.

  9. Protection by indigenous drugs against hepatotoxic effects of carbon tetrachloride A long-term study
    Karandikar SM, Joglekar GV, Chitale GK and Balwani JH. Acta Pharmacologica et Toxicologica 1963; 20: 274-280.

  10. Protection by indigenous drugs against hepatotoxic effects of carbon tetrachloride in mice
    Joglekar GV, Chitale GK, Balwani JH. Acta Pharmacologica et Toxicologica 1963; 20: 73-79.

    Mechanism Based Studies

  1. The effect of Liv.52 on liver ischemia reperfusion damage in rats
    Oracan C, Huseyin E, Ferda KC, Arif BC, Nezahat K, Asli OB, Bahadir S, Halis S, Renad M, Kamil P and Eray K. BMC Pharmacology and Toxicology 2020: 21; 2.

  2. Liv.52 protects HepG2 cells from oxidative damage induced by tert-butyl Hydroperoxide
    S. Vidyashankar, S. K Mitra, Krishna S Nandakumar. Molecular and Cellular Biochemistry 2010; 333:4148.

  3. Liv.52 regulates ethanol induced PPARγ and TNF α expression in HepG2 cells
    Mitra SK, Varma SR, Godavarthi A, Nandakumar KS. Molecular and Cellular Biochemistry 2008; 315:9-15.

  4. Protective effect of Liv.52 on Na+-K+-ATPase activity in Paracetamol-induced Hepatotoxicity
    Kala Suhas Kulkarni, Rafiq, Gopumadhavan S, Venkataranganna MV, Madhumathi BG and Mitra SK. Medicine Update 2002;10(5):53-56.

  5. Liv.52 Pretreatment Inhibits the Radiation-induced Lipid Peroxidation in Mouse Liver
    Ganapathi NG and Ganesh Chandra Jagetia. Current Science 1995;69(7):601-604.

  6. Down regulation of tumour necrosis factor activity in experimental hepatitis by a herbal formulation, Liv.52
    Roy A, Soni GR, Kolhapure RM, Karnik UR and Patki PS. Indian Journal of Experimental Biology (1994): 32, 694.

  7. Hepatoprotective effect of Liv.52 against CCl4-induced lipid peroxidation in liver of rats
    Shivani Pandey, Gujrati VR, Shanker K, Singh N and Dhawan KN. Indian Journal of Experimental Biology 1994: 32:674-675.

  8. Preventive effects of Liv.52 on the activities of cytochrome P-450 and NADPH-dependent lipid peroxidation in the liver of carbon tetrachloride-intoxicated rats.
    Goel A, Dhawan D. Medical Science Research 1991; 19: 113-116.

  9. Electron microscopic study on the effect of Liv.52 on carbon tetrachloride treated liver.
    Prasad GC. Journal of Research in Indian Medicine, Yoga and Homeopathy 1976; 4: 38-44.

    Alcohol metabolism and Alcohol-induced toxicity

  1. Role of Liv.52 A Herbal Formulation on 14C-Ethanol Metabolism and 14C Acetaldehyde Accumulation in Rat Liver
    Singh B, Dhawan D. Indian Journal of Nuclear Medicine 2000;15(1): 27-29.

  2. Hepatoprotective effects of Liv.52 on ethanol-induced liver damage in rats
    Rajat Sandhir, Gill KD. Indian Journal of Experimental Biology 1999; 37: 762-766.

  3. Bioassay for evaluation of the hepatoprotective effect of Liv.52, a polyherbal formulation, on ethanol metabolism in chronic alcohol Exposed rats
    Chauhan BL, Mohan AR, Kulkarni RD and Mitra SK. Indian Journal of Pharmacology 1994; 26:117-120.

  4. Allyl alcohol-induced hepatotoxicity in rats and its protection by Liv.52.
    Joglekar GV, Balwani JH. Journal of Experimental Medicine and Science 1967; 11: 7-9.

    NAFLD/NASH

  1. Extract of a Polyherbal Formulation Ameliorates Experimental Nonalcoholic Steatohepatitis.
    Mohammed Azeemuddin, Mohamed Rafiq, Suryakanth Dattatraya Anturlikar,Lakkavalli Mohan Sharath Kumar, Pralhad Sadashiv Patki, Uddagiri Venkanna Babu, Ramakrishnan Shyam. Journal of Traditional and Complementary Medicine 2016:6: 160-167.

  2. Liv.52 up-regulates cellular antioxidants and increase glucose uptake to circumvent oleic acid induced hepatic steatosis in HepG2 cells.
    Vidyashankar S, Sharath Kumar LM, Barooaha V, Sandeep Varma R, Nandakumar KS, Patki PS. Phytomedicine 2012: 19(13); 1156-1165.

  3. Effect of Liv.52 on membrane lipids in carbon tetrachloride-induced hepatotoxicity in rats.
    Alok Saxena, Garg NK. Indian Journal of Experimental Biology 1981; 19(9): 859-862.

  4. Effect of Liv.52 on liver lipids
    Alok Saxena, Sharma SK, Garg NK. Indian Journal of Experimental Biology 1980; 11: 1330-1331.

    Safety and Efficacy

  1. Protective Role of Liv.52 on The Toxicity of Acetaminophen During Embryogenesis in The Wistar Rats.
    Santhosh Kumar, D.P., Deecaraman, M., Vijayalaksmi, M., Ramesh Edamula, Krishnappa, H., Latha, M and GeethaRao, G. International Journal of Current Research 2015: 7: 05: 16392-16401.

  2. Protective Effect of Liv.52 on Alcohol-Induced Fetotoxicity.
    Gopumadhavan S, Jagadeesh S, Chauhan BL and Kulkarni RD. Alcoholism: Clinical and Experimental Research 1993;17(5):1089-1092.

  3. Lack of Antimutagenic activity of the Indian herbal drug Liv.52 in Salmonella typhimurium
    Eva Miadokova, Edward Gururaj M. Biologia 1991; 46(7): 657-662.

    Liv.52 AS STANDARD REFERENCE DRUG:

  1. Hepatoprotective Activity of Hydroalcohilic Extract of Annona squamosa Seeds.
    Shuchi Dave Mehta and Sarvesh Paliwal. International Journal of Pharmacognosy and Phytochemical Research 2017: 9:7: 997-1000.

  2. Evaluation of Hepatoprotective Activity of Aqueous Extract of Andrographis paniculata in Wistar Rats.
    Naveen Alasyam, Venkatanarayana Narapogu, Premendran John, Shaik Ubedulla, and Naveen Pokala. International Journal of Pharmacology and Clinical Sciences 2016: 5: 4: 113-117.

  3. Hepatoprotective effect of a polyherbal extract containing Andrographis paniculata, Tinospora cordifolia and Solanum nigrum against paracetamol induced hepatotoxicity.
    Singh DP, Awasthi H, Luqman S, Singh S, Mani D. Pharmacognosy Magazine 2015; 11(44 Suppl. 3): 375-379.

  4. Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts.
    Mahesh B U, Shrivastava S, Pragada R R, Naidu V.G.M, Sistla R. Chinese Journal of Natural Medicine 2014; 12(9): 663-671.

  5. In Vitro Antioxidant, Antibacterial, and Cytotoxic Activity and In Vivo Effect of Syngonium Podophyllum and Eichhornia Crassipes Leaf Extracts on Isoniazid Induced Oxidative Stress and Hepatic Markers.
    Shashank Kumar, Ramesh Kumar, Astha Dwivedi, and Abhay K. Pandey. Hindawi Publishing Corporation BioMedical Research International 2014:11:459452.

  6. Antihepatotoxic effect of golden berry (Physalis peruviana Linn.) in carbon tetrachloride (CCl4) intoxicated rats.
    Taj D, Khan H, Sultana V, Ara J, Ehteshamul-Haque S. Pakistan Journal of Pharmaceutical Sciences 2014; 27(3): 491-494.

  7. Evaluation of the hepato and nephron- protective effect of a polyherbal mixture using Wistar albino rats.
    Iroanya OO, Adebesin OA, Okpuzor J. Journal of Clinical and Diagnostic Research 2014 Jun, Vol-8(6): HC15-HC21.

  8. Prevention of Carbon tetrachloride (CCl4)-induced Liver Damage in Guinea Pigs by Cyphostemma digitum.
    Al-Duais MA, Al-Awthan YS, Al-Mashad A, Shamsan MA. Journal of Life Sciences 2012: 6; 137-143.

  9. Hepatoprotective and antioxidant properties of a triherbal formulation against carbon tetrachloride induced hepatotoxicity
    Iroanya O, Okpuzor J, Adebesin O. IOSR Journal of Pharmacy 2012;2(2):130-136.

  10. Scientific validation of polyherbal hepatoprotective formulation against paracetamol induced toxicity.
    Beerendra Kumar Saroj BK, Mani D, Mishra SK. Asian Pacific Journal of Tropical Biomedicine 2012: S1742-S1746.

  11. Hepatoprotective activity of Clearliv a polyherbal formulation in Wistar rats.
    Kumar E.P, Vijay Rajan R, Anil Kumar D, Parasuraman S, Emerson S.F. Archives of Medicine and Health Sciences 2013; 1: 120-125.

  12. Hepatoprotective effect of Aegle marmelos (l.) corr. leaf powder (crude) against carbon tetrachloride-induced hepatic damage in albino rats.
    Kuncha Jayachandra, Thirunavukkarasu Sivaraman. Journal of Pharmaceutical Sciences & Research 2011; 3(7):1360-1363.

  13. In vivo antioxidant activity of plant Abutilon indicum.
    Pawan K, Dhirender K, Sukhbir LK. Journal of Pharmaceutical Education and Research 2011; 2 (1):50-53.

  14. Hepatotoxic and in vivo antioxidant potential of Pandanus odoratissimus against carbon tetrachloride induced liver injury in rats.
    Ramesh Londonkar, Abhaykumar Kamble. Oriental Pharmacy and Experimental Medicine 2011; 11: 229-234.

  15. Hepatoprotective activity of Cajanus cajan against carbon tetra chloride induced liver damage.
    Singh S, Mehta A and Mehta P. International Journal of Pharmacy and Pharmaceutical Sciences 2011; 3:146-147.

  16. Hepatoprotective potential of Cordia subcordata Lam. against carbon tetra chloride (CCl4)-induced hepatotoxicity in Wistar albino rats.
    Saravana Kumar A, Gandhimathi R, Senthil Kumar KK, Kusuma Praveen Kumar. Journal of Biomedical Sciences and Research 2009; 1(1): 19-26.

  17. Hepatoprotective activity of Eugenia jambolana Lam. in carbon tetrachloride treated rats.
    Sisodia S.S, Bhatnagar M. Indian Journal of Pharmacology 2009; 41(1): 23-27.

  18. Screening of hepatoprotective effect of a herbal mixture against CCl4 induced hepatotoxicity in Swiss albino mice.
    Arun Sam Lal, Balakrishna MP, Sadasivan PK. Journal of Environmental Biology 2007; 28(2):201-207.